解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
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神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
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热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.022
更新日期:2017-12-19 00:00:00
abstract::CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplanta...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.003
更新日期:2017-12-19 00:00:00
abstract::Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal models but protective humoral immunity is difficult to induce in humans. Here we cloned and characterized rare affinity-matured human NANP-reacti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.007
更新日期:2017-12-19 00:00:00
abstract::T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumul...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.10.014
更新日期:2017-11-21 00:00:00
abstract::mTORC2 is a metabolic regulatory complex activated by PI3K. In this issue of Immunity, Kishore et al. (2017) demonstrate a specialized role for this complex in the migration of regulatory T (Treg) cells to sites of inflammation rather than their differentiation and survival. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.11.006
更新日期:2017-11-21 00:00:00
abstract::Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and e...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.10.015
更新日期:2017-11-21 00:00:00
abstract::Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.10.001
更新日期:2017-10-17 00:00:00
abstract::The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127- and CD127+ early lymp...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.09.009
更新日期:2017-10-17 00:00:00
abstract::The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.08.019
更新日期:2017-09-19 00:00:00
abstract::Transcriptional regulation during CD4+ T cell fate decisions enables their differentiation into distinct states, guiding immune responses toward antibody production via Tfh cells or inflammation by Teff cells. Tfh-Teff cell fate commitment is regulated by mutual antagonism between the transcription factors Bcl6 and Bl...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.09.001
更新日期:2017-09-19 00:00:00
abstract::Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.08.002
更新日期:2017-08-15 00:00:00
abstract::Select humans and animals control persistent viral infections via adaptive immune responses that include production of neutralizing antibodies. The precise genetic basis for the control remains enigmatic. Here, we report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.07.013
更新日期:2017-08-15 00:00:00
abstract::Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.06.017
更新日期:2017-07-18 00:00:00
abstract::Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the infla...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2017.06.008
更新日期:2017-06-20 00:00:00
abstract::Mouse blood monocytes include two main subsets usually discriminated by the expression of the Ly6C surface marker. The study by Mildner et al. (2017) in this issue of Immunity clarifies the transcriptional circuits controlling the generation of Ly6C- cells from their obligate precursors, the Ly6C+ monocytes. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.04.010
更新日期:2017-05-16 00:00:00
abstract::Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endotheliu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.04.018
更新日期:2017-05-16 00:00:00
abstract::The cytoplasm is usually a DNA-free zone, but during fertilization, sperm DNA enters oocyte cytoplasm and could potentially trigger a response. Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing that may be of particular importance during fertilization. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.04.002
更新日期:2017-04-18 00:00:00
abstract::Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor(s) that influence Treg cell phenotype and function remain largely unknown. We have shown a vital role for transforming growth factor-β (TGF-β) signals in ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.03.015
更新日期:2017-04-18 00:00:00
abstract::Mice carrying a hypomorphic point mutation in the Ptpn6 gene (Ptpn6spin mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we demonstrated that interleukin-1α (IL-1α) signaling through IL-1R and MyD88 in both stromal and immune cells drive inflammation in Ptpn6spin mice....
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.03.014
更新日期:2017-04-18 00:00:00
abstract::Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.02.011
更新日期:2017-03-21 00:00:00
abstract::The development of human innate lymphoid cells (ILCs) remains poorly characterized. In a recent issue of Cell, Lim et al. show that human peripheral-blood CD117+ ILCs harbor ILC precursors (ILCPs) derived from hematopoietic stem cells. Peripheral-blood ILCPs can generate all ILC subsets in vivo and in vitro. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.03.002
更新日期:2017-03-21 00:00:00
abstract::Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.01.004
更新日期:2017-02-21 00:00:00
abstract::A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GCs) in lymphoid tissues where self-reactive B cells expand and differentiate. In the host response to foreign antigens, follicular dendritic cells (FDCs) maintain GCs through the uptake and cycling of complement-opsonized immun...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.12.014
更新日期:2017-01-17 00:00:00
abstract::Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.12.013
更新日期:2017-01-17 00:00:00
abstract::Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.11.010
更新日期:2016-12-20 00:00:00
abstract::Activation of the innate immune response in Metazoans is initiated through the recognition of microbes by host pattern-recognition receptors. In Drosophila, diaminopimelic acid (DAP)-containing peptidoglycan from Gram-negative bacteria is detected by the transmembrane receptor PGRP-LC and by the intracellular receptor...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.10.029
更新日期:2016-11-15 00:00:00
abstract::Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.11.002
更新日期:2016-11-15 00:00:00
abstract::Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain elusive. The activation of bile acid-mediated signaling has been linked to improvement in metabolic syndromes and enhanced control of inflammation. Here, we de...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.09.008
更新日期:2016-10-18 00:00:00
abstract::Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have described these ch...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.09.014
更新日期:2016-10-18 00:00:00
abstract::B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells th...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.07.023
更新日期:2016-09-20 00:00:00
abstract::Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of aff...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2016.09.001
更新日期:2016-09-20 00:00:00
abstract::The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.07.016
更新日期:2016-09-20 00:00:00
abstract::The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by "self" MHC class I molecules in a process called "education." In humans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA) mediate NK cell education. In HLA-B(∗)27:05(+) transgenic m...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.07.005
更新日期:2016-08-16 00:00:00
abstract::Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.08.005
更新日期:2016-08-16 00:00:00
abstract::Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.07.007
更新日期:2016-08-16 00:00:00
abstract::The skin barrier is essential for host defense, but how the skin provides protection when the barrier is breached is not well understood. In this issue of Immunity, Gallo and colleagues report that keratinocytes integrate signals from antimicrobial peptides via MAVS signaling to amplify their antiviral immune response...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.07.001
更新日期:2016-07-19 00:00:00
abstract::Neutrophils are the first immune cells recruited to sites of inflammation and infection. However, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and are prone to bacterial skin infections, suggesting that allergic inflammation curtails neutrophil responses. Here we have s...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.06.025
更新日期:2016-07-19 00:00:00
abstract::Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.05.008
更新日期:2016-06-21 00:00:00
abstract::Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at the forefront of immunotherapy for cancers of various histological types. However, such immunotherapies fail to control neoplasia in a significant proportion of patients. Here, we review how a range of cancer-cell-autonomous cue...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2016.06.001
更新日期:2016-06-21 00:00:00
abstract::Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.05.009
更新日期:2016-06-21 00:00:00